e0098 HIF-1 , SDF-1 and VEGF gene expression affected by HIF-1 siRNA in MSCs
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چکیده
منابع مشابه
1(hypoxia-inducible factor-1, HIF-1) AMPK HIF-1 AMPK AMPK HIF-1 AMPK HIF-1 HIF-1 AMPK HIF-1 AMPK
The AMP-activated protein kinase is found in all eukaryotic cells. Once activated, the kinase switches on ATP-producing catabolic pathways and switches off ATP-consuming processes,both via direct phosphorylation of downstream targets, and thus is called a cellular energy regulator . A variety of novel downstream target proteins have been discovered recently, which provide new insight into eluci...
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In this study, the effects of sublethal concentrations of the Endosulfan on gene expression of hypoxia-inducible factor (HIF-1 α, HIF-2 α) and vascular endothelial growth factor (VEGF) in the gill tissue of Persian sturgeon fingerling (Acipenser persicus) were studied. A total of 360 sturgeons (average weight of 2 ± 0.12 g) exposed to concentrations of 10, 20 and 40 micrograms per liter and VEG...
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Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR. Myocardial hypoxia-inducible HIF-1 , VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia. Am J Physiol Heart Circ Physiol 293: H448–H456, 2007. First published March 16, 2007; doi:10.1152/ajpheart.00035.2007.—The systemic inflammatory response to infection is the leading cause of ...
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This review summarizes the literature describing the significance of various conditions, such as hypoxia, oxidative stress, and, above all, physical exercise, in the hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) signaling pathway mainly in skeletal muscle. HIF-1α acts as a master regulator for the expression of genes involved in the hypoxia response of most ma...
متن کاملLoss of PTEN facilitates HIF-1-mediated gene expression.
In glioblastoma-derived cell lines, PTEN does not significantly alter apoptotic sensitivity or cause complete inhibition of DNA synthesis. However, in these cell lines PTEN regulates hypoxia- and IGF-1-induced angiogenic gene expression by regulating Akt activation of HIF-1 activity. Restoration of wild-type PTEN to glioblastoma cell lines lacking functional PTEN ablates hypoxia and IGF-1 induc...
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ژورنال
عنوان ژورنال: Heart
سال: 2010
ISSN: 1355-6037
DOI: 10.1136/hrt.2010.208967.98